Depression is your inner flight mode where one has the feeling that “I want to escape or run away and go inwards to protect myself.” Normally one would do this to protect oneself from a heartbreak in a relationship or future rejection or to suppress grief of losing a loved one. The person does not want to end up in a bad relationship or experience the loss of love or whatever is close to their heart. So they would resign themselves to stay sad and in a lonely frame of mind, creating self-sabotage for themselves. The actual conflict is in the mind
Any disease is first manifested in metaphysical – meridian level and then in the physical organs of the body. Similarly, the cause of depression is the karma which causes disturbance at energy meridian level and then affects the biochemistry and activity in the brain.
In order to heal depression permanently and be happy, it is important to transform the energy at the source and work at karmic level